Hospitalization for acute medical illness is an important opportunity for applying prevention efforts. These guidelines address methods to prevent VTE in hospitalized and non-hospitalized medical patients and long-distance travelers. Access the full guidelines on the Blood Advances website: DVT prophylaxis helps prevent dangerous blood clots using compression devices, blood thinners, or simple movement strategies depending on your risk level. In response to this, an updated literature search on prophylaxis for medical patients who were hospitalized and those who were not hospitalized was carried out. The purpose of this article is to report the main findings from this updated literature search. Despite appropriate DVT prophylaxis, surgical patients may still develop both DVT and PE. A 2014 case-control study identified five independent predictors of in-hospital DVT despite chemoprophylaxis. The Padua Prediction Score is a risk assessment model (RAM) for the identification of patients at risk of VTE. Venous thromboembolism (VTE) prophylaxis consists of pharmacologic and nonpharmacologic measures to diminish the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). Treatment to prevent deep venous thrombosis is required for patients who are bedbound with major illness and/or those undergoing certain surgical procedures. Early mobilization, leg elevation, and an anticoagulant are the recommended preventive measures; patients who should not receive anticoagulants may benefit from intermittent pneumatic compression devices or elastic stockings. Evidence supporting a threshold at which pharmacologic prophylaxis shows clearer VTE reduction (Caprini ≥7) comes from a meta-analysis of 13 studies. In total joint arthroplasty, a threshold of ≥10 has been used to identify patients who may benefit from traditional anticoagulants vs aspirin. In acutely ill hospitalized medical patients, the panel recommends inpatient over inpatient plus extended duration outpatient VTE prophylaxis (strong recommendation, moderate certainty). DVT prophylaxis involves a range of preventive measures that aim to reduce the risk of DVT and subsequent complications.